2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W008429
    m-PEG2-Amine 31576-51-9 99.89%
    m-PEG2-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG2-Amine
  • HY-120537
    m-PEG5-CH2COOH 16142-03-3 99.00%
    m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-CH2COOH
  • HY-140033
    Propargyl-PEG3-amine 932741-19-0 ≥98.0%
    Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-amine
  • HY-W051634
    Propargyl-PEG2-amine 944561-44-8 99.64%
    Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-amine
  • HY-W025896
    Boc-NH-PEG4 106984-09-2
    Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG4
  • HY-140915
    Biotin-PEG4-Picolyl azide 2222687-71-8 98.66%
    Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Picolyl azide
  • HY-140456
    Azido-PEG12-acid 2152679-71-3 99.81%
    Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-acid
  • HY-W047688
    tert-Butyl (10-aminodecyl)carbamate 216961-61-4
    tert-Butyl (10-aminodecyl)carbamate (1-Boc-1,10-diaminodecane) can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. tert-Butyl (10-aminodecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (10-aminodecyl)carbamate
  • HY-W101722
    tert-Butyl (9-aminononyl)carbamate 510754-90-2 ≥98.0%
    tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (9-aminononyl)carbamate
  • HY-133378
    Biotin-PEG24-NHS ester ≥98.0%
    Biotin-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG24-NHS ester
  • HY-130898
    BM-PEG3 86099-06-1 ≥98.0%
    BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    BM-PEG3
  • HY-141016
    (S,R,S)-AHPC-PEG2-acid 2172820-09-4 98.88%
    (S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (S,R,S)-AHPC-PEG2-acid
  • HY-130474
    Azido-PEG6-NHS ester 2055014-64-5 98.85%
    Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-NHS ester
  • HY-124323
    m-PEG4-NHS ester 622405-78-1
    m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-NHS ester
  • HY-120702
    N-Boc-PEG5-bromide 1392499-32-9 ≥98.0%
    N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG5-bromide
  • HY-W007545
    NH2-PEG3 6338-55-2 99.87%
    NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1).
    NH2-PEG3
  • HY-138382
    m-PEG4-PFP ester 2952895-31-5 ≥98.0%
    m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-PFP ester
  • HY-140697
    m-PEG-OH (MW5000) 9004-74-4 ≥98.0%
    m-PEG-OH (MW5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-OH (MW5000)
  • HY-140661
    Azide-PEG-amine (MW 2000)
    Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-amine (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-amine (MW 2000)
  • HY-134720
    Amine-PEG4-Desthiobiotin 2306109-91-9 99.23%
    Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG4-Desthiobiotin
PROTAC Linkers Isoform Comparison

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